{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Name:{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester
CAS No.:449758-33-2
Molecular Formula:C₂₇H₃₃N₇O₄
Molecular Weight:519.604
Hs Code.:

Synonyms:{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

There total 5 articles about {(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 449758-33-2
{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaN₃; glacial AcOH / 2 h / 20 °C

2: NH₄Cl; EDC; HOAt / iPr₂NEt / dimethylformamide / 20 °C

3: Burges reagent / tetrahydrofuran

4: 750 mg / NH₃/EtOH; H₂ / Raney Ni

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; iPr₂NEt / dimethylformamide / 20 °C

With sodium azide; 1-hydroxy-7-aza-benzotriazole; Burgess Reagent; ethanol; ammonia; hydrogen; ammonium chloride; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; nickel; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm030303e

Reference yield:

: 116570-12-8
2-Tetrazol-1-yl-benzoic acid

: 449758-33-2
{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NH₄Cl; EDC; HOAt / iPr₂NEt / dimethylformamide / 20 °C

2: Burges reagent / tetrahydrofuran

3: 750 mg / NH₃/EtOH; H₂ / Raney Ni

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; iPr₂NEt / dimethylformamide / 20 °C

With 1-hydroxy-7-aza-benzotriazole; Burgess Reagent; ethanol; ammonia; hydrogen; ammonium chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; nickel; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm030303e

Reference yield:

: 449758-25-2
2-Tetrazol-1-yl-benzonitrile

: 449758-33-2
{(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 750 mg / NH₃/EtOH; H₂ / Raney Ni

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; iPr₂NEt / dimethylformamide / 20 °C

With 1-hydroxy-7-aza-benzotriazole; ethanol; ammonia; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; nickel; In N,N-dimethyl-formamide;
DOI:10.1021/jm030303e