116570-12-8

Basic information

• Product Name: 2-(1H-TETRAZOL-1-YL)BENZOIC ACID
• Synonyms: 2-(1H-TETRAZOL-1-YL)BENZOIC ACID;AKOS BB-8759;IFLAB-BB F3284-8095;OTAVA-BB BB7020410144;2-(Tetrazol-1-yl)benzoic acid;2-(1,2,3,4-tetrazol-1-yl)benzoic acid;2-(1-tetrazolyl)benzoic acid;ChemDiv2_001227
• CAS NO: 116570-12-8
• Molecular Formula: C₈H₆N₄O₂
• Molecular Weight: 190.16
• Mol File: 116570-12-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 428.9°Cat760mmHg
• Flash Point: 213.2°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 4.03E-08mmHg at 25°C
• CAS DataBase Reference: 2-(1H-TETRAZOL-1-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-TETRAZOL-1-YL)BENZOIC ACID(116570-12-8)
• EPA Substance Registry System: 2-(1H-TETRAZOL-1-YL)BENZOIC ACID(116570-12-8)

Safety Data

• Hazardous Substances Data: 116570-12-8(Hazardous Substances Data)

Usage

General Description

2-(1H-tetrazol-1-yl)benzoic acid, also known as Losartan potassium, is a pharmaceutical drug primarily used to treat high blood pressure and certain heart conditions. It belongs to the class of medications called angiotensin II receptor antagonists. Losartan works by blocking the action of a natural substance called angiotensin II in the body, which helps to relax blood vessels and lowers blood pressure. It is typically taken orally once a day, with or without food. Common side effects include dizziness, lightheadedness, and an increased level of potassium in the blood. 2-(1H-TETRAZOL-1-YL)BENZOIC ACID is used widely for its antihypertensive properties and is a key component in several medications.

InChI:InChI=1/C8H6N4O2/c13-8(14)6-3-1-2-4-7(6)12-5-9-10-11-12/h1-5H,(H,13,14)/p-1

Upstream product

• 118-92-3 anthranilic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 288-94-8 1H-tetrazole 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 449758-33-2 {(R)-1-Benzyl-2-oxo-2-[(S)-2-(2-tetrazol-1-yl-benzylcarbamoyl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester 
• 449756-94-9 2-Tetrazol-1-yl-benzylamine 
• 449758-25-2 2-Tetrazol-1-yl-benzonitrile 
• 449758-24-1 2-Tetrazol-1-yl-benzamide 

Relevant articles and documents

Cross-linked poly (4-vinylpyridine) supported azide ion as a versatile and recyclable polymeric reagent for synthesis of 1-substituted-1H-1,2,3,4- tetrazoles

Cross-linked poly (4-vinylpyridine) supported azide ion, [P 4-VP]N3, is easily prepared and used as an efficient polymeric reagent for synthesis of 1-substituted-1H-1,2,3,4-tetrazoles via condensation reaction of azide ion, primary aromatic amines, and triethyl orthoformate in glacial acetic acid. After optimization of the reaction conditions, a wide variety of primary aromatic amines were also subjected to preparation of the corresponding 1-aryl-1 H-1,2,3,4- tetrazoles using [P 4-VP]N3 under heterogeneous conditions. In this method, the reaction times were very short and the isolated yields were excellent (90-98 %). 1-Aryl-1H-1,2,3,4- tetrazole products were characterized by Fourier transform infrared (FT-IR) and some of them were also characterized by proton nuclear magnetic resonance (1H NMR) spectroscopy, and physical properties were compared with the literature values of known compounds. The spent polymeric reagent were regenerated quantitatively and reused for several cycles without significant loss of their activity.

The impact of binding site waters on the activity/selectivity trade-off of Janus kinase 2 (JAK2) inhibitors

Structure based optimization of B39, an indazole-based low micromolar JAK2 virtual screening hit is reported. Analysing the effect of certain modifications on the activity and selectivity of the analogues suggested that these parameters are influenced by

1,6 - SUBSTITUTED (3R,6R) -3- (2,3-DIHYDRO-1H-INDEN-2-YL)-2,5-PIPERAZINEDIONE DERIVATIVES AS OXYTOCIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PRE-TERM LABOUR, DYSMENORRHEA AND ENDOMETRIOSIS

The present invention relates to compound S of Formula (I).