5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Base Information

Chemical Name:5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine
CAS No.:118533-05-4
Molecular Formula:C₃₆H₃₇N₅O₁₀
Molecular Weight:699.717
Hs Code.:

5'-O-acetyl-2',3'-O-methoxymethylene-N<sup>2</sup>-(4,4',4''-trimethoxytrityl)guanosine

Synonyms:5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Suppliers and Price of 5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Chemical Property:

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Technology Process of 5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

There total 4 articles about 5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 123154-89-2,123154-91-6
Acetic acid (3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 49757-42-8
4,4',4''-trimethoxytrityl chloride

: 118533-05-4
5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 6979-94-8
2',3',5'-tri-O-acetyl-guanosine

: 118533-05-4
5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / hydroxylammonium sulphate dihydrate, triethylamine / methanol / 33 h / Ambient temperature

2: trimethylsilyl chloride / dimethylformamide / 4.5 h

3: 60 percent / N,N-dimethylaminopyridine, triethylamine / dimethylformamide / 0.5 h

With dmap; chloro-trimethyl-silane; hydroxylammonium sulphate dihydrate; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 28220-16-8
5'-O-acetylguanosine

: 118533-05-4
5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl chloride / dimethylformamide / 4.5 h

2: 60 percent / N,N-dimethylaminopyridine, triethylamine / dimethylformamide / 0.5 h

With dmap; chloro-trimethyl-silane; triethylamine; In N,N-dimethyl-formamide;