(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

Base Information

Chemical Name:(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile
CAS No.:214967-08-5
Molecular Formula:C₂₂H₃₇NO₃Si
Molecular Weight:391.626
Hs Code.:

Synonyms:(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

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Technology Process of (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

There total 3 articles about (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 214967-21-2
(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-hydroxy-pentanenitrile

: 214967-08-5
(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/S0040-4039(98)01506-8

Reference yield:

: 14869-00-2,128821-01-2
1-(benzyloxy)butan-2-ol

: 214967-08-5
(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BF₃*OEt₂, 2.) K₂CO₃ / 1.) CH₂Cl₂, 0 deg C -> RT, 2.) MeOH, RT

2: 90 percent / 18-crown-6 / methanol / Ambient temperature

3: 87 percent / imidazole / dimethylformamide / 60 °C

With 1H-imidazole; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01506-8

Reference yield:

: 214967-07-4
(S)-2-[(R)-1-(1-Benzyloxymethyl-propoxy)-ethyl]-oxirane

: 214967-08-5
(3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 18-crown-6 / methanol / Ambient temperature

2: 87 percent / imidazole / dimethylformamide / 60 °C

With 1H-imidazole; 18-crown-6 ether; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01506-8