3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

Base Information

Chemical Name:3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile
CAS No.:1449420-90-9
Molecular Formula:C₁₉H₁₇NO₆
Molecular Weight:355.347
Hs Code.:

Synonyms:3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

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Chemical Property of 3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

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Technology Process of 3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

There total 6 articles about 3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 121-98-2
methyl 4-methoxybenzoate

: 1291486-12-8
2,3-dimethoxy-4,5-methylenedioxyphenylacetonitrile

: 1449420-90-9
3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

Guidance literature:: 2,3-dimethoxy-4,5-methylenedioxyphenylacetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

methyl 4-methoxybenzoate; In tetrahydrofuran; mineral oil; Reflux; Inert atmosphere;
DOI:10.1021/np400310m

Reference yield:

: 23731-65-9
2,3-dimethoxy-4,5-methylenedioxybenzaldehyde

: 1449420-90-9
3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 20 °C

2.1: thionyl chloride / benzene / 0.67 h / 48 - 50 °C

3.1: dibenzo-18-crown-6 / acetonitrile / 10 h / 50 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.2: Reflux; Inert atmosphere

With sodium tetrahydroborate; dibenzo-18-crown-6; thionyl chloride; sodium hydride; In tetrahydrofuran; methanol; acetonitrile; mineral oil; benzene;
DOI:10.1021/np400310m

Reference yield:

: 1449420-89-6
C₁₀H₁₁ClO₄

: 1449420-90-9
3-(4-methoxyphenyl)-3-oxo-2-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibenzo-18-crown-6 / acetonitrile / 10 h / 50 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: Reflux; Inert atmosphere

With dibenzo-18-crown-6; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1021/np400310m