2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

Base Information

Chemical Name:2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide
CAS No.:1309788-72-4
Molecular Formula:C₅₀H₇₄N₄O₄Si₃
Molecular Weight:879.418
Hs Code.:

2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

Synonyms:2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

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Chemical Property of 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

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Technology Process of 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

There total 16 articles about 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1309788-71-3
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]amide

: 74-88-4
methyl iodide

: 1309788-72-4
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

Reference yield:

: 2979-19-3
3,3-dimethylcyclohexanone

: 1309788-72-4
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: hydrazine hydrate / methanol / 1 h / Reflux

3.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: triethylamine / dmap / tetrahydrofuran / 1.17 h / 20 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice

6.2: pH 5

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere

7.2: 2 h

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

8.2: pH 5

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 °C

10.1: 1H-imidazole / N,N-dimethyl-formamide / 8 h / 20 °C / Cooling with ice

11.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With 1H-imidazole; potassium phosphate; water; iodine; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 1309788-72-4
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]methylamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 2 h / 20 °C

2.1: dmap / tetrahydrofuran / 2 h / 20 °C

3.1: lithium diisopropyl amide; Triisopropyl borate / hexane; tetrahydrofuran / 2.5 h / -5 °C

3.2: Cooling with ice

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice

5.2: pH 5

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere

6.2: 2 h

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

7.2: pH 5

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 °C

9.1: 1H-imidazole / N,N-dimethyl-formamide / 8 h / 20 °C / Cooling with ice

10.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With 1H-imidazole; potassium phosphate; Triisopropyl borate; water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium diisopropyl amide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide;