1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid

Base Information

• Chemical Name: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid
• CAS No.: 243646-85-7
• Molecular Formula: C₂₉H₂₉N₃O₈
• Molecular Weight: 547.565

Synonyms:1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid

Chemical Property of 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid

Chemical Property:

Purity/Quality:

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Technology Process of 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid

There total 2 articles about 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hoffer's chlorosugar (3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3) → 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid (243646-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: C₄F₉SO₃K; hexamethyldisilazane; TMSCl / acetonitrile / 16 h / Heating

1.2: 55 percent / NaOH / methanol / 1 h / 20 °C

2.1: pyridine / 16 h / 20 °C

With pyridine; chloro-trimethyl-silane; C₄F₉SO₃K; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile;

DOI:10.1021/tx980255e

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(2-deoxy-D-erythro-pentofuranosyl)cyanuric acid → 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]cyanuric acid + 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid (243646-85-7)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1021/tx980255e

Reference yield: 68.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]cyanuric acid (243646-85-7) → 1-{2-deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl}cyanuric acid

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/tx980255e

upstream raw materials:

4,4'-dimethoxytrityl chloride

Hoffer's chlorosugar

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