(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

Base Information

Chemical Name:(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate
CAS No.:1379514-65-4
Molecular Formula:C₂₈H₃₅N₃O₅
Molecular Weight:493.603
Hs Code.:

Synonyms:(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

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Chemical Property of (R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

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Technology Process of (R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

There total 9 articles about (R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: [(3R)-quinuclidin-3-yl]2-amino-2-phenylacetate bis hydrochloride salt

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 1379514-65-4
(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

Guidance literature:: [(3R)-quinuclidin-3-yl]2-amino-2-phenylacetate bis hydrochloride salt; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.166667h;

2-(tert-butoxycarbonylamino)-2-phenylacetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 1379514-65-4
(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C

3.2: 15 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 2835-06-5
phenylglycin

: 1379514-65-4
(R)-quinuclidin-3-yl 2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; acetone / 1 h / 20 °C

1.2: pH 5

2.1: triethylamine / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C

2.2: 15 h / 20 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone;