tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate
CAS No.:1431473-05-0
Molecular Formula:C₁₁H₂₁NO₃
Molecular Weight:215.293
Hs Code.:
Mol file:1431473-05-0.mol

Synonyms:tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Suppliers and Price of tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2R,5R)-1-N-BOC-5-HYDROXY-2-METHYLPIPERIDINE 95.00%
5MG
$ 498.37

Alichem
(2R,5R)-tert-Butyl5-hydroxy-2-methylpiperidine-1-carboxylate
100mg
$ 712.40

AK Scientific
Tert-Butyl(2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate
250mg
$ 375.00

AK Scientific
Tert-Butyl(2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate
100mg
$ 293.00

Total 7 raw suppliers

Chemical Property of tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Chemical Property:

Boiling Point:301.4±35.0 °C(Predicted)
PKA:14.75±0.40(Predicted)
Density:1.067±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(2R,5R)-1-N-BOC-5-HYDROXY-2-METHYLPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

There total 16 articles about tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 285995-17-7
(R)-2-Hydroxy-(R)-5-methylpiperidine-(R)-amine-N-oxide

: 24424-99-5
di-tert-butyl dicarbonate

: 1431473-05-0
tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Guidance literature:: With triethylamine; In ethanol; at 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1431473-04-9
benzyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

: 1431473-05-0
tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate;

Reference yield:

: 1431473-24-3
(2R,5S)-benzyl 5-hydroxy-2-methylpiperidine-1-carboxylate

: 1431473-05-0
tert-butyl (2R,5R)-5-hydroxy-2-methylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / -25 - 20 °C / Inert atmosphere

2: sodium hydroxide / methanol; water; tetrahydrofuran / 20 °C

3: hydrogen; palladium 10% on activated carbon / ethyl acetate

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; methanol; water; ethyl acetate;