5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

Base Information

Chemical Name:5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole
CAS No.:1146943-24-9
Molecular Formula:C₁₃H₁₄FN₃O₂S
Molecular Weight:295.337
Hs Code.:

Synonyms:5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

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Chemical Property of 5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

Chemical Property:

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Technology Process of 5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

There total 3 articles about 5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146943-23-8
5-amino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

: 75-36-5
acetyl chloride

: 1146943-24-9
5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

Guidance literature:: 5-amino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole; acetyl chloride; In toluene; for 12h; Reflux;

With ammonia; In ethanol; water; at 20 ℃; for 0.5h;

Reference yield:

: 1146943-21-6
2-fluoro-4-methyl-5-(methylthio)aniline

: 1146943-24-9
5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / acetic acid / 3.25 h / 5 °C

1.2: 5 °C

2.1: tetrahydrofuran / 2 h / 20 °C

2.2: 3 h / Reflux

2.3: pH 7

3.1: toluene / 12 h / Reflux

3.2: 0.5 h / 20 °C

With sulfuric acid; sodium nitrite; In tetrahydrofuran; acetic acid; toluene;

Reference yield:

: 1146943-22-7
2-fluoro-4-methyl-5-methylthiophenylhydrazine

: 1146943-24-9
5-acetylamino-1-(2-fluoro-4-methyl-5-methylthiophenyl)-3-hydroxypyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 20 °C

1.2: 3 h / Reflux

1.3: pH 7

2.1: toluene / 12 h / Reflux

2.2: 0.5 h / 20 °C

In tetrahydrofuran; toluene;