2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI)

Base Information

• Chemical Name: 2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI)
• CAS No.: 213899-37-7
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.225
• Mol file: 213899-37-7.mol

Synonyms:2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI)

Chemical Property of 2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI)

There total 3 articles about 2H-Pyran-2-one,tetrahydro-3-methyl-6-(1-methylethyl)-,(3R,6S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

C9H16O2 → (3RS,6SR)-3-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (213899-37-7,648434-43-9,770729-49-2)

Guidance literature:

C₉H₁₆O₂; With (triphenylphosphine)copper(I) hydride hexamer; In benzene; at 20 ℃; for 4h; Inert atmosphere;

With 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve;

With tetrapropylammonium perruthennate; In dichloromethane; at 20 ℃; for 16h; optical yield given as %de; stereoselective reaction;

DOI:10.1002/anie.201004619

Reference yield:

C13H22Si2 + isoprene (78-79-5,9003-31-0) → (3RS,6SR)-3-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (213899-37-7,648434-43-9,770729-49-2) + (3SR,6SR)-3-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (213899-37-7,648434-43-9,770729-49-2) + (4SR,6SR)-4-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (57058-20-5,97309-52-9,191917-39-2)

Guidance literature:

Multistep reaction. Title compound not separated from byproducts;

DOI:10.1039/b404175e

Reference yield:

C13H22Si2 + isoprene (78-79-5,9003-31-0) → (3RS,6SR)-3-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (213899-37-7,648434-43-9,770729-49-2) + (3SR,6SR)-3-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (213899-37-7,648434-43-9,770729-49-2) + (4SR,6SR)-4-methyl-6-(prop-2'-yl)tetrahydropyran-2-one (57058-20-5,97309-52-9,191917-39-2)

Guidance literature:

Multistep reaction. Title compound not separated from byproducts;

DOI:10.1039/b404175e

upstream raw materials:

isoprene