(R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

Base Information

Chemical Name:(R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester
CAS No.:111945-03-0
Molecular Formula:C₃₇H₇₄O₆Si₄
Molecular Weight:727.333
Hs Code.:

(R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

Synonyms:(R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

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Chemical Property of (R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

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Technology Process of (R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

There total 1 articles about (R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 111945-03-0
(R)-4-((1R,3S,5S,7R,8S,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-1,3,7,12-tetrakis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1.32 g / N,N-dimethylaminopyridine, Et₃N / CH₂Cl₂ / 1 h

2: 180 mg / Br₂ / acetic acid / 1 h / Ambient temperature

3: 98 mg / Li₂CO₃, LiBr / dimethylformamide / 4 h / 80 °C

4: 63 mg / Zn dust / acetone; acetic acid / 0.5 h / Ambient temperature

5: 30 percent H₂O₂, 2 N NaOH / ethanol / 4 h / Ambient temperature

6: diethyl ether

7: 43 mg / Cr(OAc)2 / tetrahydrofuran; ethanol / 2 h / Ambient temperature

8: 38 mg / NaBH₄ / propan-2-ol / 1 h

9: 112 mg / 2 N LiOH / methanol / 1 h / Heating

10: diethyl ether / Ambient temperature

11: acetonitrile / 0.5 h / 60 °C

With dmap; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; bromine; lithium carbonate; chromium(II) acetate; triethylamine; lithium bromide; zinc; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;
DOI:10.1248/cpb.34.2890