N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

Base Information

Chemical Name:N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide
CAS No.:172992-37-9
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

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Chemical Property of N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

Chemical Property:

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Technology Process of N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

There total 4 articles about N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 172992-36-8
N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-hydroxy-butylcarbamoyl)-ethyl]-butyramide

: 172992-37-9
N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃;
DOI:10.1016/0040-4039(95)01996-U

Reference yield:

: 34805-17-9
methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride

: 172992-37-9
N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / triethylamine / CH₂Cl₂ / 2 h / 25 °C

2: 1.) 1 M NaOH, 2.) 3 M HCl / 1.) MeOH, 25 deg C, 4 h

3: 90 percent / DCC, 1-hydroxybenzotriazole / CH₂Cl₂ / 16 h / 25 °C

4: 91 percent / DMSO, oxalyl chloride / CH₂Cl₂ / -78 °C

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/0040-4039(95)01996-U

Reference yield:

: 172992-34-6
3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester

: 172992-37-9
N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1 M NaOH, 2.) 3 M HCl / 1.) MeOH, 25 deg C, 4 h

2: 90 percent / DCC, 1-hydroxybenzotriazole / CH₂Cl₂ / 16 h / 25 °C

3: 91 percent / DMSO, oxalyl chloride / CH₂Cl₂ / -78 °C

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/0040-4039(95)01996-U