3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester

Base Information

• Chemical Name: 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester
• CAS No.: 172992-34-6
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 172992-34-6.mol

Synonyms:3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester

Chemical Property of 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester

There total 1 articles about 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride (34805-17-9) + butyryl chloride (141-75-3) → 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester (172992-34-6)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1016/0040-4039(95)01996-U

Reference yield: 96.0%

3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester (172992-34-6) → 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid (172992-35-7)

Guidance literature:

With sodium hydroxide; In methanol; at 25 ℃; for 4h;

DOI:10.1016/S0040-4039(97)10542-1

Reference yield:

3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester (172992-34-6) → N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide (937377-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. LiOH / tetrahydrofuran / 16 h / 20 °C

2: 4.73 g / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂; ethyl acetate / 4 h / 20 °C

3: 99 percent / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/ja0705801

upstream raw materials:

methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride

butyryl chloride

Downstream raw materials:

3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid

N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide

(4-{7-[3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester

3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester