4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester
• CAS No.: 232600-03-2
• Molecular Formula: C₄₅H₄₆Cl₂N₁₁O₁₂PS
• Molecular Weight: 1066.87

Synonyms:4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

Chemical Property of 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

There total 4 articles about 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C66H64Cl2N11O14PS (199436-70-9) → 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester (232600-03-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at -50 ℃; for 0.0833333h;

DOI:10.1080/07328319808004743

Reference yield:

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine (85231-45-4) → 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester (232600-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (PhO)2POCl; C₅H₅N / 20 °C

2: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; chlorophosphoric acid diphenyl ester; In dichloromethane;

DOI:10.1016/S0040-4039(03)00322-8

Reference yield:

C41H39Cl2N5O9P(1-) → 4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester (232600-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (PhO)2POCl; C₅H₅N / 20 °C

2: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; chlorophosphoric acid diphenyl ester; In dichloromethane;

DOI:10.1016/S0040-4039(03)00322-8

upstream raw materials:

C₆₆H₆₄Cl₂N₁₁O₁₄PS

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine

Downstream raw materials:

4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

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