4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester
CAS No.:544710-53-4
Molecular Formula:C₄₇H₄₈Cl₂N₁₁O₁₃PS
Molecular Weight:1108.91
Hs Code.:

4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of 4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

There total 5 articles about 4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199436-70-9
C₆₆H₆₄Cl₂N₁₁O₁₄PS

: 544710-53-4
4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

2: C₅H₅N / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; In dichloromethane;
DOI:10.1016/S0040-4039(03)00322-8

Reference yield:

: 108-24-7
acetic anhydride

: 232600-03-2
4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-((2-cyano-ethylsulfanyl)-{(2R,3S,5R)-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-yloxy}-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

: 544710-53-4
4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With pyridine; for 15h; Ambient temperature;
DOI:10.1080/07328319808004743

Reference yield:

: 85231-45-4
N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine

: 544710-53-4
4-Oxo-pentanoic acid (2R,3S,5R)-2-[{(2R,3S,5R)-2-acetoxymethyl-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (PhO)2POCl; C₅H₅N / 20 °C

2: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

3: C₅H₅N / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; chlorophosphoric acid diphenyl ester; In dichloromethane;
DOI:10.1016/S0040-4039(03)00322-8