8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine

Base Information

• Chemical Name: 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine
• CAS No.: 1029857-56-4
• Molecular Formula: C₃₀H₃₇N₁₁O₇
• Molecular Weight: 663.693
• Mol file: 1029857-56-4.mol

Synonyms:8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine

Chemical Property of 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine

There total 1 articles about 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

8-(3-acetylphenyl)-2'-deoxyguanosine + 6-azidohexanoic acid (79598-53-1) → 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine (1029857-56-4)

Guidance literature:

With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/ja8039019

Reference yield: 96.0%

2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) (919988-17-3) + 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine (1029857-56-4) → mAGD3 (1029857-60-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; at 20 ℃; pH=7.0; aq. phosphate buffer;

DOI:10.1021/ol800701j

Reference yield: 95.0%

propargyl 2,2,5-trimethyl-1,3-dioxane-5-carboxylate (919988-15-1) + 8-(3-acetylphenyl)-(3',5'-bis-O-(6-azidohexanoyloxy))-2'-deoxyquanosine (1029857-56-4) → mAGD2 (1029857-58-6)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; at 20 ℃; pH=7.0; aq. phosphate buffer;

DOI:10.1021/ol800701j

upstream raw materials:

6-azidohexanoic acid

Downstream raw materials:

mAGD₂

mAGD₃

C₄₆H₆₁N₁₁O₁₅

C₃₆H₄₅N₁₁O₉