Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide

Base Information

• Chemical Name: Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide
• CAS No.: 111681-27-7
• Molecular Formula: C₁₅H₂₈N₄
• Molecular Weight: 264.414
• Mol file: 111681-27-7.mol

Synonyms:Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide

Chemical Property of Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide

There total 2 articles about Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[3-(4-Methyl-piperazin-1-yl)-propyl]-phosphoramidic acid diethyl ester (117727-03-4) + Cyclohexyl isocyanate (3173-53-3) → Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide (111681-27-7)

Guidance literature:

With potassium carbonate; In xylene; for 12h; Heating;

DOI:10.1055/s-1988-27590

Reference yield: 71.0%

1-Cyclohexyl-3-[3-(4-methyl-piperazin-1-yl)-propyl]-urea (111681-34-6) → Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide (111681-27-7)

Guidance literature:

With potassium carbonate; 4-bromobenzenesulfonyl chloride; N-benzyl-N,N,N-triethylammonium chloride; In benzene; for 2h; Heating;

DOI:10.1055/s-1987-27992

Reference yield: 94.0%

Cyclohexyl-[3-(4-methyl-piperazin-1-yl)-propyl]-carbodiimide (111681-27-7) + methyl iodide (74-88-4) → C16H31N4(1+)*I(1-) (117733-91-2)

Guidance literature:

In diethyl ether; Ambient temperature;

DOI:10.1055/s-1988-27590

upstream raw materials:

1-Cyclohexyl-3-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

[3-(4-Methyl-piperazin-1-yl)-propyl]-phosphoramidic acid diethyl ester

Cyclohexyl isocyanate

Downstream raw materials:

TIMEOUT: 5s

C₁₆H₃₁N₄⁽¹⁺⁾*I^(1-)

C₁₆H₃₁N₄⁽¹⁺⁾*I^(1-)