diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate

Base Information

• Chemical Name: diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate
• CAS No.: 286961-94-2
• Molecular Formula: C₁₅H₂₃O₅P
• Molecular Weight: 314.318
• Mol file: 286961-94-2.mol

Synonyms:diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate

Chemical Property of diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate

There total 1 articles about diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-Diethyl 2-ethoxyethenylphosphonate (13868-21-8,39171-20-5) + benzaldehyde (100-52-7) → diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate (286961-94-2)

Guidance literature:

(E)-Diethyl 2-ethoxyethenylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;

DOI:10.1021/jo000149t

Reference yield:

diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate (286961-94-2) → diethyl (E)-1-formyl-2-phenylvinylphosphonate (286962-09-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo000149t

Reference yield:

diethyl (E)-1-ethoxy-3-hydroxy-3-phenyl-1-propen-2-ylphosphonate (286961-94-2) → diethyl 4,5-dihydro-5-phenyl-1H-pyrazol-4-ylphosphonate

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 °C

2: hydrazine monohydrate / ethanol / 11 h / 20 °C

With hydrazine hydrate; trifluoroacetic acid; In ethanol; dichloromethane; 1: Rearrangement / 2: cyclocondensation;

DOI:10.1021/jo000149t

upstream raw materials:

(E)-Diethyl 2-ethoxyethenylphosphonate

benzaldehyde

Downstream raw materials:

diethyl (E)-1-formyl-2-phenylvinylphosphonate