(rac)-3-phenyl-3-methylcyclopentanone

Base Information

• Chemical Name: (rac)-3-phenyl-3-methylcyclopentanone
• CAS No.: 85662-51-7
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.243
• Mol file: 85662-51-7.mol

Synonyms:(rac)-3-phenyl-3-methylcyclopentanone

Chemical Property of (rac)-3-phenyl-3-methylcyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (rac)-3-phenyl-3-methylcyclopentanone

There total 38 articles about (rac)-3-phenyl-3-methylcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-Methyl-2-cyclopenten-1-one (2758-18-1) + phenylboronic acid (98-80-6) → (rac)-3-phenyl-3-methylcyclopentanone (85662-51-7)

Guidance literature:

With [2,2]bipyridinyl; palladium(II) trifluoroacetate; sodium 2,2,2-trifluoroacetate; In water; at 100 ℃; pH=8.2;

DOI:10.1021/acscatal.5b01272

Reference yield: 93.0%

3-Methyl-2-cyclopenten-1-one (2758-18-1) + phenylboronic acid (98-80-6) → (R)-methyl 3-oxo-1-phenylcyclopentanecarboxylate (53750-06-4,85662-51-7,131726-64-2,110508-59-3)

Guidance literature:

With silver hexafluoroantimonate; PdCl₂-(R,R-PhBOX); In methanol; water; at 40 ℃; for 24h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/chem.201200694

Reference yield: 92.0%

2-phenyl-2-methylcyclobutanone (75750-06-0) + 1-lithiomethyl phenyl selenoxide (85662-39-1) → (rac)-3-phenyl-3-methylcyclopentanone (85662-51-7)

Guidance literature:

In tetrahydrofuran; 1.) -78 deg C, 10 min, 2.) reflux, 5 min;

DOI:10.1021/jo00160a034

upstream raw materials:

2-phenyl-2-methylcyclobutanone

1-lithiomethyl phenyl selenoxide

2-hydroxy-5-methyl-5-phenylcyclopent-2-en-1-one

2-trimethylsilyloxy-5-phenyl-1,5-hexadiene

Downstream raw materials:

4-methyl-4-phenylcyclopent-2-en-1-one

3-Methyl-3-p-nitrophenylcyclopentanon

3,5-Dimethyl-3-phenylcyclopentanon

2,2,3-Trimethyl-3-phenylcyclopentanon