N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

Base Information

Chemical Name:N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide
CAS No.:1026926-78-2
Molecular Formula:C₂₇H₂₂Cl₂N₄O₃
Molecular Weight:521.403
Hs Code.:

<i>N</i>-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

Synonyms:N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

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Chemical Property of N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

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Technology Process of N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

There total 7 articles about N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-chlorobenzyloxy)-3-chlorobenzenamine

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1026926-78-2
N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

Guidance literature:: With pyridine hydrochloride; In 2-methoxy-ethanol; Heating;
DOI:10.1021/jm040159c

Reference yield:

: 25351-89-7
N-(2-hydroxy-4-nitrophenyl)acetamide

: 1026926-78-2
N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / K₂CO₃ / dimethylformamide / 60 °C

2: H₂ / Pd/C / tetrahydrofuran / 3 h / 28 - 30 °C / 2585.74 Torr

3: 524 g / toluene / 16 h / 90 °C

4: 42 percent / various solvent(s) / 20 h / 250 - 255 °C

5: 65 percent / POCl₃ / bis-(2-methoxy-ethyl) ether / 0.75 h / 100 - 102 °C

6: pyridine hydrochloride / 2-methoxy-ethanol / Heating

With hydrogen; pyridine hydrochloride; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 2-methoxy-ethanol; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm040159c

Reference yield:

: 116496-76-5
4-acetamido-3-ethoxynitrobenzene

: 1026926-78-2
N-{4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / tetrahydrofuran / 3 h / 28 - 30 °C / 2585.74 Torr

2: 524 g / toluene / 16 h / 90 °C

3: 42 percent / various solvent(s) / 20 h / 250 - 255 °C

4: 65 percent / POCl₃ / bis-(2-methoxy-ethyl) ether / 0.75 h / 100 - 102 °C

5: pyridine hydrochloride / 2-methoxy-ethanol / Heating

With hydrogen; pyridine hydrochloride; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 2-methoxy-ethanol; diethylene glycol dimethyl ether; toluene;
DOI:10.1021/jm040159c