2H-Benzimidazole-2-thione,1,3-dihydro-1-(2-hydroxyethyl)-(9CI)

Base Information

• Chemical Name: 2H-Benzimidazole-2-thione,1,3-dihydro-1-(2-hydroxyethyl)-(9CI)
• CAS No.: 26345-73-3
• Molecular Formula: C₉H₁₀N₂OS
• Molecular Weight: 194.257
• Mol file: 26345-73-3.mol

Synonyms:1-Benzimidazoleethanol,2-mercapto- (8CI); 2-Benzimidazolinethione, 1-(2-hydroxyethyl)- (7CI); 1-(2-Hydroxyethyl)-2-mercaptobenzimidazole;2-Mercapto-1-(2-hydroxyethyl)benzimidazole; 2-Mercapto-1-benzimidazoleethanol

Chemical Property of 2H-Benzimidazole-2-thione,1,3-dihydro-1-(2-hydroxyethyl)-(9CI)

Chemical Property:

• PSA: 73.04000
• LogP: 1.69120

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Benzimidazole-2-thione,1,3-dihydro-1-(2-hydroxyethyl)-(9CI)

There total 7 articles about 2H-Benzimidazole-2-thione,1,3-dihydro-1-(2-hydroxyethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(triphenylmethyl)sulfanylbenzimidazole (137213-71-9) + 2-bromoethanol (540-51-2) → 1-(2-hydroxyethyl)-1H-benzo[d]imidazole-2(3H)-thione (26345-73-3)

Guidance literature:

(triphenylmethyl)sulfanylbenzimidazole; With potassium hydroxide; In acetone; for 0.0833333h;

2-bromoethanol; In acetone; at 0 ℃; for 8h;

With acetic acid; In methanol; for 0.5h; Reflux;

DOI:10.1016/j.poly.2021.115647

Reference yield: 59.0%

S-trityl benzimadazole-2-thione + 2-bromoethanol (540-51-2) → 1-(2-hydroxyethyl)-1H-benzo[d]imidazole-2(3H)-thione (26345-73-3)

Guidance literature:

S-trityl benzimadazole-2-thione; With potassium hydroxide; In acetone; for 0.0833333h; Inert atmosphere;

2-bromoethanol; In acetone; at 0 - 20 ℃; for 8h;

Reference yield:

(triphenylmethyl)sulfanylbenzimidazole (137213-71-9) → 1-(2-hydroxyethyl)-1H-benzo[d]imidazole-2(3H)-thione (26345-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / acetone / 0.08 h

1.2: 8 h / 0 °C

2.1: acetic acid / methanol / 0.5 h / Reflux

With acetic acid; potassium hydroxide; In methanol; acetone;

DOI:10.1002/chem.201605238

upstream raw materials:

(triphenylmethyl)sulfanylbenzimidazole

2,3-dihydrobenzimidazol-2-thione

2-bromoethanol

benzimidazole-2-thione

Refernces

• 1、 Banerjee, Mainak,Karri, Ramesh,Chalana, Ashish,Das, Ranajit,Rai, Rakesh Kumar,Rawat, Kuber Singh,Pathak, Biswarup,Roy, Gouriprasanna. "Protection of Endogenous Thiols against Methylmercury with Benzimidazole-Based Thione by Unusual Ligand-Exchange Reactions". . p. 5696 - 5707. Retrieved 2017/04/28.