(1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate

Base Information

• Chemical Name: (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate
• CAS No.: 865469-43-8
• Molecular Formula: C₂₅H₃₃N₃O₇
• Molecular Weight: 487.553

Synonyms:(1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate

Chemical Property of (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate

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Technology Process of (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate

There total 1 articles about (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H30N2O3*ClH (864824-91-9) + 4-Nitrophenyl chloroformate (7693-46-1) → (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate (865469-43-8)

Guidance literature:

With pyridine; In dichloromethane; at 10 ℃; for 16h;

DOI:10.1021/jm801616e

Reference yield: 63.0%

C13H27NS*ClH (865469-42-7) + (1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate (865469-43-8) → C32H55N3O4S (865469-44-9)

Guidance literature:

With 4-methyl-morpholine; In acetonitrile; at 20 ℃; for 8h;

Reference yield:

(1R,2S,5S)-methyl-6,6-dimethyl-3-((S)-2-(1-methylcyclohexyl)-2-((4-nitrophenoxy)carbonylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylate (865469-43-8) + (S)-2-amino-3,3-dimethylbutyl ethylcarbamate hydrochloride (1152269-22-1) → C28H48N4O6

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 17h;

DOI:10.1021/jm801616e

upstream raw materials:

C₁₈H₃₀N₂O₃*ClH

4-Nitrophenyl chloroformate

Downstream raw materials:

C₃₂H₅₅N₃O₄S

C₂₆H₄₅N₃O₅

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