(R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 153710-18-0
• Molecular Formula: C₁₂H₁₉NO₃S
• Molecular Weight: 257.354
• Mol file: 153710-18-0.mol

Synonyms:(R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

Chemical Property of (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

There total 7 articles about (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-valinol (2026-48-4,473-75-6) + p-toluenesulfonyl chloride (98-59-9) → (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide (153710-18-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol102956x

Reference yield: 75.0%

Methyl (R)-N-<(4-methylphenyl)sulfonyl>valinate (153710-20-4) → (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide (153710-18-0)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jo00112a028

Reference yield: 39.0%

(CH3)Cu(CN)(1-)*Li(1+)*LiBr=(CH3)Cu(CN)Li*LiBr + (2R,3S)-3-methyl-1-<(4-methylphenyl)sulfonyl>-2-azidirinemethanol (153829-45-9) → (R)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide (153710-18-0) + (1R,2S)-2-Amino-1-ethyl-N-<(4-methylphenyl)sulfonyl>-1-propanol + (1S,2S)-2-Amino-1-ethyl-N-<(4-methylphenyl)sulfonyl>-1-propanol

Guidance literature:

In tetrahydrofuran; diethyl ether; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(00)60142-9

upstream raw materials:

(2R,3S)-3-methyl-1-<(4-methylphenyl)sulfonyl>-2-azidirinemethanol

Methyl (R)-N-<(4-methylphenyl)sulfonyl>valinate

(R)-2-amino-3-methylbutanol

p-toluenesulfonyl chloride

Downstream raw materials:

C₁₉H₂₉NO₅S

C₁₉H₂₉NO₅S

(R)-2-isopropyl-1-tosylaziridine

(R)-3-methyl-2-(tosylamino)butyl (2R,3S,4E)-3-[(tert-butyldimethylsilyl)oxy]-2-methyl-5-phenylpent-4-enoate