16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

Base Information

Chemical Name:16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol
CAS No.:812653-12-6
Molecular Formula:C₃₃H₄₉NO₆S
Molecular Weight:587.821
Hs Code.:

Synonyms:16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

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Chemical Property of 16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

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Technology Process of 16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

There total 11 articles about 16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3-(16-benzyloxyhexadec-1-enyl)-5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indole

: 812653-12-6
16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr;
DOI:10.1021/jm0493616

Reference yield:

: 59101-27-8
15-bromopentadecane-1-ol

: 812653-12-6
16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / Heating

2.1: acetonitrile / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 0 °C

3.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C

3.3: 49 percent / tetrahydrofuran; hexane / -78 - 0 °C

4.1: 94 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

With n-butyllithium; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; acetonitrile; 3.3: Wittig reaction;
DOI:10.1021/jm0493616

Reference yield:

: 88210-96-2
5,6-dimethoxyindole-2-carboxylic acid

: 812653-12-6
16-[5,6-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 61 percent / Cu; quinoline / Heating

2.1: 86 percent / phosphoryl chloride / 0 - 40 °C

3.1: NaOH / CH₂Cl₂ / 20 °C

3.2: 26 percent / CH₂Cl₂ / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0 °C

4.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C

4.3: 49 percent / tetrahydrofuran; hexane / -78 - 0 °C

5.1: 94 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

With quinoline; sodium hydroxide; n-butyllithium; hydrogen; copper; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; 2.1: Vilsmeier formylation / 4.3: Wittig reaction;
DOI:10.1021/jm0493616