2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

Base Information

Chemical Name:2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide
CAS No.:1402603-16-0
Molecular Formula:C₂₉H₂₈N₄O₃
Molecular Weight:480.566
Hs Code.:

Synonyms:2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

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Chemical Property of 2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

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Technology Process of 2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

There total 19 articles about 2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402604-01-6
C₃₄H₃₆N₄O₅

: 1402603-16-0
2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 1h;

Reference yield:

: 1247898-38-9
tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

: 1402603-16-0
2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

3: potassium hydroxide; water / methanol / 5 h / 20 °C

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 90 °C

5: trifluoroacetic acid / chloroform / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1402603-16-0
2-(4-(trans-1-amino-3-hydroxy-3-methylcyclobutyl)phenyl)-N-methyl-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazine-9-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

1.2: 3 h / 20 - 26 °C

1.3: 20 °C / Heating

2.1: sulfuric acid / 20 °C / Reflux

3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / chloroform / 24 h / 20 °C / Cooling with ice

4.1: tetrahydrofuran / 2.25 h / -40 - 0 °C

4.2: 20 °C

5.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 2 h / 80 °C

5.2: 2 h / 20 °C / Cooling with ice

6.1: 1,4-dioxane / 3 h / 70 °C

7.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

8.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

9.1: potassium hydroxide; water / methanol / 5 h / 20 °C

10.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 90 °C

11.1: trifluoroacetic acid / chloroform / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; diphenyl phosphoryl azide; water; isopropylmagnesium chloride; potassium acetate; benzotriazol-1-ol; caesium carbonate; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;