tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

Base Information

Chemical Name:tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate
CAS No.:1247898-38-9
Molecular Formula:C₁₆H₂₂BrNO₃
Molecular Weight:356.26
Hs Code.:
Mol file:1247898-38-9.mol

Synonyms:tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

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Chemical Property of tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

Chemical Property:

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Technology Process of tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

There total 9 articles about tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1402603-97-7
trans-3-amino-3-(4-bromophenyl)-1-methylcyclobutanol

: 1247898-38-9
tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

Guidance literature:: In 1,4-dioxane; at 70 ℃; for 3h;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1247898-38-9
tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

1.2: 3 h / 20 - 26 °C

1.3: 20 °C / Heating

2.1: sulfuric acid / 20 °C / Reflux

3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / chloroform / 24 h / 20 °C / Cooling with ice

4.1: tetrahydrofuran / 2.25 h / -40 - 0 °C

4.2: 20 °C

5.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 2 h / 80 °C

5.2: 2 h / 20 °C / Cooling with ice

6.1: 1,4-dioxane / 3 h / 70 °C

With tetrapropylammonium perruthennate; sulfuric acid; diphenyl phosphoryl azide; isopropylmagnesium chloride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; chloroform;

Reference yield:

: 1364663-42-2
methyl 1-(4-bromophenyl)-3-oxocyclobutane-1-carboxylate

: 1247898-38-9
tert-butyl trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2.25 h / -40 - 0 °C

1.2: 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 2 h / 80 °C

2.2: 2 h / 20 °C / Cooling with ice

3.1: 1,4-dioxane / 3 h / 70 °C

With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; 1,4-dioxane;