2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide

Base Information

• Chemical Name: 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide
• CAS No.: 173267-12-4
• Molecular Formula: C₁₁H₁₂F₃NOS
• Molecular Weight: 263.284
• Mol file: 173267-12-4.mol

Synonyms:2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide

Chemical Property of 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide

There total 3 articles about 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,2,2-trifluoro-N-(2-(phenylthio)ethyl)acetamide (173267-11-3) + methyl iodide (74-88-4) → 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide (173267-12-4)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.2091

Reference yield:

2-(phenylthio)ethanamine (2014-75-7) → 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide (173267-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / pyridine

2: 77 percent / dimethylformamide

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.2091

Reference yield:

(phenylthio)acetonitrile (5219-61-4) → 2,2,2-Trifluoro-N-methyl-N-(2-phenylsulfanyl-ethyl)-acetamide (173267-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄, AlCl₃ / diethyl ether

2: 96 percent / pyridine

3: 77 percent / dimethylformamide

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.2091

upstream raw materials:

2,2,2-trifluoro-N-(2-(phenylthio)ethyl)acetamide

methyl iodide

2-(phenylthio)ethanamine

(phenylthio)acetonitrile