4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine

Base Information

Chemical Name:4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine
CAS No.:1432293-74-7
Molecular Formula:C₂₁H₂₉ClN₁₀O
Molecular Weight:472.981
Hs Code.:

Synonyms:4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine

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Chemical Property of 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine

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Technology Process of 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine

There total 10 articles about 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432293-21-4
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

: 1H-1,2,4-triazole-1-carboximidamide monohydrochloride

: 1432293-74-7
4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine

Guidance literature:: With triethylamine; In methanol; N,N-dimethyl-formamide; at 70 ℃; for 2h;

Reference yield:

: 21874-45-3
1-(tert-butylcarbamoyl)prop-1-en-2-yl 3,5-diamino-6-chloropyrazine-2-carboxylate

: 1432293-74-7
4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidinomethyl]-4-phenethylpiperidine-1-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / tert-butyl methyl ether; tetrahydrofuran / 20 °C

2: acetonitrile / 48 h / 70 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

With water; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 775530-61-5
3,5-diamino-6-chloro-N-[(methylsulfanyl)methanimidoyl]pyrazine-2-carboxamide

: 1432293-74-7
4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidinomethyl]-4-phenethylpiperidine-1-carboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 48 h / 70 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;