N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

Base Information

Chemical Name:N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine
CAS No.:1432293-21-4
Molecular Formula:C₂₀H₂₇ClN₈O
Molecular Weight:430.94
Hs Code.:

Synonyms:N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

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Chemical Property of N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

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Technology Process of N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

There total 6 articles about N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432291-72-9
4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidinomethyl]-4-phenethylpiperidine-1-carboxylic acid tert-butyl ester

: 1432293-21-4
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1432291-72-9
4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1432293-21-4
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1432293-21-4
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

1.2: 4 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / tert-butyl methyl ether; tetrahydrofuran / 20 °C

3.1: acetonitrile / 48 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With trifluorormethanesulfonic acid; water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; acetonitrile;