4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

Base Information

Chemical Name:4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile
CAS No.:1383677-07-3
Molecular Formula:C₂₁H₁₇N₇O₂S
Molecular Weight:431.478
Hs Code.:

Synonyms:4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

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Chemical Property of 4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

Chemical Property:

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Technology Process of 4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

There total 7 articles about 4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383677-25-5
(7-(2-(methylsulfonyl)phenyl)quinoxalin-6-yl)methanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1383677-07-3
4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 3.5h;

Reference yield:

: 67073-39-6
4-nitro-5-chloro-1,2-phenylenediamine

: 1383677-07-3
4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol; water / 1 h / Reflux

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / Inert atmosphere; Reflux

3.1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / Reflux

3.2: 0.17 h / 20 °C

4.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

4.2: 24.33 h / 0 - 20 °C

5.1: potassium carbonate / trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex / 1,4-dioxane; water / 50 °C / Inert atmosphere

6.1: dibenzoyl peroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrachloromethane / Reflux

7.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

8.1: triphenylphosphine; water / tetrahydrofuran / 20 - 75 °C

8.3: pH ~ 14

9.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 3.5 h / 120 °C

With hydrogenchloride; sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tin(II) chloride dihdyrate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium nitrite; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 6-methyl-7-nitroquinoxaline

: 1383677-07-3
4-amino-6-((7-(2-(methylsulfonyl)phenyl)-quinoxalin-6-yl)methylamino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / Reflux

1.2: 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.58 h / 0 °C

2.2: 24.33 h / 0 - 20 °C

3.1: potassium carbonate / trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex / 1,4-dioxane; water / 50 °C / Inert atmosphere

4.1: dibenzoyl peroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrachloromethane / Reflux

5.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

6.1: triphenylphosphine; water / tetrahydrofuran / 20 - 75 °C

6.3: pH ~ 14

7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 3.5 h / 120 °C

With hydrogenchloride; sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tin(II) chloride dihdyrate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium nitrite; dibenzoyl peroxide; trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;