(3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one

Base Information

• Chemical Name: (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one
• CAS No.: 1613377-94-8
• Molecular Formula: C₂₅H₂₁NO₃S
• Molecular Weight: 415.513
• Mol file: 1613377-94-8.mol

Synonyms:(3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one

Chemical Property of (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one

There total 14 articles about (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-4-(3-phenyl-1-tosyl-1H-indol-2-yl)but-3-en-2-one → (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one (1613377-94-8)

Guidance literature:

With iodine; In toluene; at 150 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/acs.orglett.6b00805

Reference yield: 83.0%

4-methyl-N-{2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}-benzenesulfonamide (340696-22-2) → (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one (1613377-94-8)

Guidance literature:

4-methyl-N-{2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}-benzenesulfonamide; With sodium acetate; palladium diacetate; p-benzoquinone; at 100 ℃; for 16h;

With iodine; at 100 ℃; for 3h;

DOI:10.1021/acs.joc.8b02470

Reference yield: 83.0%

4-methyl-N-{2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}-benzenesulfonamide (340696-22-2) → (3E)-4-[1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one (1613377-94-8) + C25H21NO3S

Guidance literature:

4-methyl-N-{2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}-benzenesulfonamide; With palladium diacetate; acetic acid; p-benzoquinone; at 100 ℃; for 16h;

With iodine; at 100 ℃; for 3h;

DOI:10.1021/acs.joc.8b02470

upstream raw materials:

N-tosylfurfurylamine

2-(hydroxy(phenyl)methyl)-1-(4-methylphenylsulfonamido)benzene

4-methyl-N-{2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}-benzenesulfonamide

2-methylfuran