5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester
• CAS No.: 208335-88-0
• Molecular Formula: C₁₇H₁₉NO₆
• Molecular Weight: 333.341

Synonyms:5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester

Chemical Property of 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester

There total 2 articles about 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 5-amino-2-furoate (22600-30-2) + 3-(3,4-dimethoxy-phenyl)-propionyl chloride (51842-87-6) → 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester (208335-88-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo980008f

Reference yield:

3,4-methoxycinnamic acid (2107-70-2) → 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester (208335-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂ / 12 h / Ambient temperature

2: 90 percent / pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.1021/jo980008f

Reference yield: 69.0%

4-bromo-2-methylbut-1-ene (20038-12-4) + 5-[3-(3,4-Dimethoxy-phenyl)-propionylamino]-furan-2-carboxylic acid methyl ester (208335-88-0) → 5-[[3-(3,4-Dimethoxy-phenyl)-propionyl]-(3-methyl-but-3-enyl)-amino]-furan-2-carboxylic acid methyl ester (208335-26-6)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 24h;

DOI:10.1021/jo980008f

upstream raw materials:

methyl 5-amino-2-furoate

3-(3,4-dimethoxy-phenyl)-propionyl chloride

3,4-methoxycinnamic acid

Downstream raw materials:

5-[[3-(3,4-Dimethoxy-phenyl)-propionyl]-(3-methyl-but-3-enyl)-amino]-furan-2-carboxylic acid methyl ester

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