22600-30-2

Basic information

• Product Name: METHYL 5-AMINO-2-FUROATE
• Synonyms: METHYL 5-AMINO-2-FUROATE;5-Aminofuran-2-carboxylic acid methyl ester~5-Amino-2-furoic acid methyl ester~Methyl 5-aminofuran-2-carboxylate;5-Amino-2-furoicacidmethylester;5-aminofuran-2-carboxylic acid methyl ester;2-Furancarboxylicacid,5-amino-,methylester(9CI);Methyl 5-aminofuran-2-carboxylate;Methyl 2-aMino-furan-5-carboxylate;5-Aminofuroic acid methyl ester
• CAS NO: 22600-30-2
• Molecular Formula: C₆H₇NO₃
• Molecular Weight: 141.12
• Product Categories: CARBOXYLICESTER;AMINOACID
• Mol File: 22600-30-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 132-134°C
• Boiling Point: 277.9 °C at 760 mmHg
• Flash Point: 121.9 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0.00439mmHg at 25°C
• Refractive Index: 1.527
• PKA: -0.67±0.10(Predicted)
• BRN: 1365799
• CAS DataBase Reference: METHYL 5-AMINO-2-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-AMINO-2-FUROATE(22600-30-2)
• EPA Substance Registry System: METHYL 5-AMINO-2-FUROATE(22600-30-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 22-24/25-36/37-26
• Hazardous Substances Data: 22600-30-2(Hazardous Substances Data)

Usage

General Description

METHYL 5-AMINO-2-FUROATE is a chemical compound with the molecular formula C6H7NO3. It is a furoic acid derivative that is commonly used in organic synthesis as a starting material in the production of pharmaceuticals, dyes, and other fine chemicals. The compound is a white powder with a molecular weight of 141.12 g/mol and has a melting point of approximately 141-144°C. It is soluble in methanol, ethanol, and acetone, and is considered to be moderately toxic if ingested or inhaled. METHYL 5-AMINO-2-FUROATE is an important building block in the synthesis of various organic compounds and is used in the pharmaceutical and chemical industries.

InChI:InChI=1/C6H7NO3/c1-9-6(8)4-2-3-5(7)10-4/h2-3H,7H2,1H3

Upstream product

• 1874-23-3 methyl 5-nitrofuran-2-carboxylate 
• 611-13-2 2-furoic acid methyl ester 

Downstream Products

• 177913-38-1 4-amino-5-(benzenesulfonyl)-1-hydroxycyclohexa-2,4-dienecarboxylic acid methyl ester 
• 208335-80-2 5-[2-(3,4-dimethoxyphenyl)acetylamino]furan-2-carboxylic acid methyl ester 
• 304696-24-0 5-(3-benzyl-ureido)-furan-2-carboxylic acid 
• 68967-53-3 2-benzoylamino-furo[2,3-d]thiazole-5-carboxylic acid 

Relevant articles and documents

Toward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides

Crescent-shaped polyamides composed of aromatic amino acids, i.e., 1-methyl-1H-imidazole Im, 1-methyl-1H-pyrrole Py, and 3-hydroxy-1H-pyrrole Hp, bind in the minor groove of DNA as 2:1 and 1:1 ligand/DNA complexes. DNA-Sequence specificity can be attributed to shape-selective recognition and the unique corners or pairs of corners presented by each heterocycle(s) to the edges of the base pairs on the floor of the minor groove. Here we examine the relationship between heterocycle structure and DNA-sequence specificity for a family of five-membered aromatic amino acids. By means of quantitative DNase-I footprinting, the recognition behavior of polyamides containing eight different aromatic amino acids, i.e., 1-methyl-1H-pyrazole Pz, 1H-pyrrole Nh, 5-methylthiazole Nt, 4-methylthiazole Th, 3-methylthiophene Tn, thiophene Tp, 3-hydroxythiophene Ht, and furan Fr, were compared with the polyamides containing the parent-ring amino acids Py, Im, and Hp for their ability to discriminate between the four Watson - Crick base pairs in the DNA minor groove. Analysis of the data and molecular modeling showed that the geometry inherent to each heterocycle plays a significant role in the ability of polyamides to differentiate between DNA sequences. Binding appears sensitive to changes in curvature complementarity between the polyamide and DNA. The Tn/Py pair affords a modest 3-fold discrimination of T · A vs. A · T and suggests that an S-atom in the thiophene ring prefers to lie opposite T not A.

Diarylamide compound and application thereof

The invention discloses a use of a diarylamide compound with a structure shown as a formula (I), and a pharmaceutically acceptable salt thereof in the preparation of a medicine serving as a urea transporter inhibitor, and the novel diarylamide compound. T

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.