2-(TRIFLUOROMETHYL)-4(3H)-QUINAZOLINONE

Base Information

• Chemical Name: 2-(TRIFLUOROMETHYL)-4(3H)-QUINAZOLINONE
• CAS No.: 26059-81-4
• Molecular Formula: C9H5 F3 N2 O
• Molecular Weight: 214.147
• Hs Code.: 2933990090
• Mol file: 26059-81-4.mol

Synonyms:4(1H)-Quinazolinone,2-(trifluoromethyl)- (9CI); 2-Trifluoromethylquinazolin-4(3H)-one

Chemical Property of 2-(TRIFLUOROMETHYL)-4(3H)-QUINAZOLINONE

Chemical Property:

• Vapor Pressure: 0.025mmHg at 25°C
• Melting Point: 248-251°
• Refractive Index: 1.565
• Boiling Point: 247.9°Cat760mmHg
• PKA: -2.90±0.20(Predicted)
• Flash Point: 103.7°C
• PSA: 45.75000
• Density: 1.51g/cm³
• LogP: 1.94190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(trifluoromethyl)-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(TRIFLUOROMETHYL)-4(3H)-QUINAZOLINONE

There total 4 articles about 2-(TRIFLUOROMETHYL)-4(3H)-QUINAZOLINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

anthranilic acid amide (28144-70-9,88-68-6) + trifluoroacetic acid (76-05-1) → 2-(trifluoromethyl)-quinazolin-4(3H)-one (26059-81-4)

Guidance literature:

for 0.05h; microwave irradiation;

Reference yield: 32.0%

ethyl trifluoroacetate, (383-63-1) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(trifluoromethyl)quinazolin-4-ol (26059-81-4)

Guidance literature:

ethyl trifluoroacetate,; anthranilic acid amide; With sodium ethanolate; In ethanol; for 24h; Reflux;

With hydrogenchloride; pH=2 - 3;

DOI:10.1016/j.ejmech.2019.06.030

Reference yield: 31.0%

ethyl trifluoroacetate, (383-63-1) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(trifluoromethyl)-quinazolin-4(3H)-one (26059-81-4)

Guidance literature:

anthranilic acid amide; With sodium ethanolate; In ethanol; at 60 ℃; for 1h;

ethyl trifluoroacetate,; In ethanol; at 60 ℃; for 20h;

upstream raw materials:

ethyl trifluoroacetate,

anthranilic acid amide

trifluoroacetic acid

Downstream raw materials:

4-chloro-2-trifluoromethyl quinazoline

4-hydrazino-2-trifluoromethylquinazoline

(2-(trifluoromethyl)quinazolin-4-yl)glycine