tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate
CAS No.:263383-23-9
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40312-14-9
N'-hydroxy-2-methylbenzamidine

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 263383-23-9
tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; at 80 ℃; for 5h;

Reference yield:

: C₁₉H₂₇N₃O₄

: 263383-23-9
tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1021/jm200825u

Reference yield:

: 529-19-1
2-Methylbenzonitrile

: 263383-23-9
tert-butyl 4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / Reflux

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

2.2: 20 °C

3.1: N,N-dimethyl-formamide / 120 °C

With hydroxylamine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200825u