(2-bromo-3-pyridinyl)methyl diphenylphosphinate

Base Information

• Chemical Name: (2-bromo-3-pyridinyl)methyl diphenylphosphinate
• CAS No.: 264625-60-7
• Molecular Formula: C₁₈H₁₅BrNO₂P
• Molecular Weight: 388.2
• Mol file: 264625-60-7.mol

Synonyms:(2-bromo-3-pyridinyl)methyl diphenylphosphinate

Chemical Property of (2-bromo-3-pyridinyl)methyl diphenylphosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-bromo-3-pyridinyl)methyl diphenylphosphinate

There total 3 articles about (2-bromo-3-pyridinyl)methyl diphenylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(2-bromopyrid-3-yl)methanol (131747-54-1) + Diphenylphosphinic chloride (1499-21-4) → (2-bromo-3-pyridinyl)methyl diphenylphosphinate (264625-60-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4039(99)02298-4

Reference yield:

2-bromo-3-picoline (3430-17-9) → (2-bromo-3-pyridinyl)methyl diphenylphosphinate (264625-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide

2: CaCO₃ / H₂O; dioxane

3: 76 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h

With dmap; N-Bromosuccinimide; triethylamine; calcium carbonate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jo010371d

Reference yield:

2-bromo-3-bromomethylpyridine (94446-97-6) → (2-bromo-3-pyridinyl)methyl diphenylphosphinate (264625-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: CaCO₃ / H₂O; dioxane

2: 76 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h

With dmap; triethylamine; calcium carbonate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jo010371d

upstream raw materials:

(2-bromopyrid-3-yl)methanol

Diphenylphosphinic chloride

2-bromo-3-picoline

2-bromo-3-bromomethylpyridine

Downstream raw materials:

3-(azidomethyl)-2-phenylpyridine

Refernces

• 1、 Clive,Kang. "Synthesis of biaryls by intramolecular radical transfer in phosphinates". . p. 6083 - 6091. Retrieved 2007/10/03.