131747-54-1

Basic information

• Product Name: 2-BROMO-3-(HYDROXYMETHYL)PYRIDINE
• Synonyms: (2-BROMO-PYRIDIN-3-YL)-METHANOL;2-BROMONICOTINYL ALCOHOL;2-BROMO-3-(HYDROXYMETHYL)PYRIDINE;2-BROMO-3-PYRIDINEMETHANOL;2-Bromo-3-(hydroxymethyl)pyridine 2-Bromonicotinyl Alcohol;(2-Bromo-3-pyridyl)methanol;(2-Bromo-3-pyridinyl)methanol
• CAS NO: 131747-54-1
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• Product Categories: Bromopyridines;Halopyridines
• Mol File: 131747-54-1.mol
• Article Data: 34

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 307.384 °C at 760 mmHg
• Flash Point: 139.701 °C
• Appearance: /
• Density: 1.668
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in methanol(almost transparency).
• PKA: 12.96±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-3-(HYDROXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-(HYDROXYMETHYL)PYRIDINE(131747-54-1)
• EPA Substance Registry System: 2-BROMO-3-(HYDROXYMETHYL)PYRIDINE(131747-54-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 131747-54-1(Hazardous Substances Data)

Usage

Uses

2-Bromo-3-bromomethylpyridine was obtained by reaction of the 2-bromo-3-hydroxymethylpyridine with PBr3 in dichloromethane. Reactant in the synthesis of 3-[2-bromophenyl(or pyridyl)methoxymethyl]benzo[4,5]imidazo[2,1-b]thiazoles.

InChI:InChI=1/C6H6BrNO/c7-6-5(4-9)2-1-3-8-6/h1-3,9H,4H2

Upstream product

• 35905-85-2 2-bromonicotinic acid 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 52718-95-3 2-bromonicotinic acid methyl ester 
• 543-27-1 isobutyl chloroformate 
• 541-41-3 chloroformic acid ethyl ester 
• 109-04-6 2-bromo-pyridine 
• 3430-17-9 2-bromo-3-picoline 
• 1036408-89-5 C₉H₈BrNO₄ 
• 28539-02-8 1-Hydroxymethyl-1H-benzotriazole 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 94446-97-6 2-bromo-3-bromomethylpyridine 

Downstream Products

• 932042-98-3 2-bromo-3-vinylpyridine 
• 264625-65-2 3-(azidomethyl)-2-phenylpyridine 
• 1037830-89-9 2-bromo-3-(2-prop-1-ynyl-phenoxymethyl)-pyridine 
• 947395-88-2 [2-(phenylethynyl)pyridin-3-yl]methanol 
• 1205555-51-6 [2-(p-tolylethynyl)pyridin-3-yl]methanol 
• 1609627-79-3 C₁₇H₁₇NO₄ 
• 1609627-78-2 C₁₇H₁₇NO₃ 
• 1609627-85-1 C₁₈H₂₀F₃NO₅S 
• 1206975-97-4 C₁₃H₁₂BrNO 
• 94446-97-6 2-bromo-3-bromomethylpyridine 
• 264625-60-7 (2-bromo-3-pyridinyl)methyl diphenylphosphinate 
• 874484-20-5 S29434 
• 194151-94-5 [2-(propan-2-yl)pyridin-3-yl]methanol 

Relevant articles and documents

Morita-Baylis-Hillman Reaction of β,β-Disubstituted Enones: An Enantioselective Organocatalytic Approach for the Synthesis of Cyclopenta[b]annulated Arenes and Heteroarenes

The first enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (MBH) reaction of sterically highly demanding β,β-disubstituted enones is presented. The MBH reaction of β,β-disubstituted-α,β-unsaturated electron-withdrawing systems was previously considered to be unfeasible. Towards this end, designer substrates, which under simple and practical reaction conditions generate a variety of cyclopenta[b]annulated arenes and heteroarenes in excellent enantiopurities and near-quantitative yields in remarkably short reaction times, are described. The reason for the unusually facile nature of this reaction is attributed to the synergy guided and entropically favored intramolecular reaction. Further, this strategy provides easy access to a substantial number of bioactive natural products and pharmaceutically significant compounds.

SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND APPLICATION THEREOF

Provided are a substituted heteroaryl compound, and a composition and application thereof. The compound is a compound as represented by formula (I) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as represented by formula (I). Also provided is a drug composition containing the compound. The compound and the drug composition can adjust activity of a JAK kinase, particularly activity of TYK2, and are used for preventing, handling, treating and relieving diseases or disorder mediated by the activity of the JAK kinase.

SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF

Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.