N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1622242-90-3
Molecular Formula:C₂₇H₂₃ClN₂O₃S
Molecular Weight:491.01
Hs Code.:

Synonyms:N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Chemical Property of N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 9 articles about N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1622243-08-6
5-(4-chlorophenyl)-6-phenylpyridin-2-amine

: 1622242-90-3
N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 89284-11-7
5,6-dibromopyridin-2-ylamine

: 1622242-90-3
N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; methanol; toluene / 12 h / 110 °C / Inert atmosphere

2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: ethyl 2-(4-(ethylthio)phenyl)acetate

: 1622242-90-3
N-(5-(4-chlorophenyl)-6-phenylpyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

2: water; sodium hydroxide / ethanol / 12 h / 20 °C

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 1 h / 20 °C

With water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane; ethyl acetate;