6-Amino-2,3-dibromopyridine

Base Information

• Chemical Name: 6-Amino-2,3-dibromopyridine
• CAS No.: 89284-11-7
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.908
• Hs Code.: 2933399090
• Mol file: 89284-11-7.mol

Synonyms:Pyridine,6-amino-2,3-dibromo- (7CI);5,6-Dibromopyridin-2-amine;

Chemical Property of 6-Amino-2,3-dibromopyridine

Chemical Property:

• Vapor Pressure: 0.0013mmHg at 25°C
• Melting Point: 154-155 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.672
• Boiling Point: 298.087 °C at 760 mmHg
• PKA: 1.19±0.10(Predicted)
• Flash Point: 134.078 °C
• PSA: 38.91000
• Density: 2.147 g/cm³
• LogP: 2.77000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

5,6-Dibromopyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Amino-2,3-dibromopyridine

There total 8 articles about 6-Amino-2,3-dibromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 5,6-dibromopyridin-2-ylamine (89284-11-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 1h; Cooling with ice;

Reference yield:

2,3,6-tribromopyridine (2402-92-8) → 5,6-dibromopyridin-2-ylamine (89284-11-7) + 3,6-dibromo-[2]pyridylamine (503425-86-3)

Guidance literature:

With ammonium hydroxide; at 150 - 160 ℃;

Reference yield:

2,4,6-tribromopyridine (2408-70-0) → 5,6-dibromopyridin-2-ylamine (89284-11-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NH₃ / 160 °C / Nebenprodukt Nr_. 2: 6-Brom-pyridin-2,4-diyldiamin

2: palladium/charcoal; methanol. NaOH / Hydrogenation

3: acetic acid; bromine

With ammonium hydroxide; sodium hydroxide; palladium on activated charcoal; bromine; acetic acid;

upstream raw materials:

2-Amino-6-bromopyridine

2,3,6-tribromopyridine

bromine

acetic acid

Refernces

• 1、 Che, Jinxin,Jin, Zegao,Yan, Fangjie,You, Jieqiong,Xie, Jiangfeng,Chen, Binhui,Cheng, Gang,Zhu, Hong,He, Qiaojun,Hu, Yongzhou,Yang, Bo,Cao, Ji,Dong, Xiaowu. "Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis". . p. 8621 - 8643. Retrieved 2021/06/28.
• 2、 Wu, Yanwei,Xu, Shanghui,Wang, Hong,Shao, Dongxu,Qi, Qiqi,Lu, Yi,Ma, Li,Zhou, Jianhua,Hu, Wei,Gao, Wei,Chen, Jianbin. "Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions". . p. 16144 - 16150. Retrieved 2021/07/19.