5,6-Dibromopyridin-2-amine

Base Information

• Chemical Name: 5,6-Dibromopyridin-2-amine
• CAS No.: 89284-11-7
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.908
• Hs Code.: 2933399090
• European Community (EC) Number: 893-137-8
• DSSTox Substance ID: DTXSID80546850
• Wikidata: Q82424775
• Mol file: 89284-11-7.mol

Synonyms:5,6-DIBROMOPYRIDIN-2-AMINE;89284-11-7;6-Amino-2,3-dibromopyridine;MFCD00234045;5,6-Dibromo-2-pyridinamine;2-Pyridinamine, 5,6-dibromo-;5,6-Dibromo-pyridin-2-ylamine;Dibromopyridin-2-amine;SCHEMBL989145;AMY9302;DTXSID80546850;SETWFMYLBKUBKF-UHFFFAOYSA-N;5 pound not6-Dibromopyridin-2-amine;AKOS024258209;CS-W005529;DS-3147;PB43762;SY022449;EN300-199194

Chemical Property of 5,6-Dibromopyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.0013mmHg at 25°C
• Melting Point: 154-155 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.672
• Boiling Point: 298.087 °C at 760 mmHg
• PKA: 1.19±0.10(Predicted)
• Flash Point: 134.078 °C
• PSA: 38.91000
• Density: 2.147 g/cm³
• LogP: 2.77000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 251.87207
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dibromopyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1Br)Br)N

Technology Process of 5,6-Dibromopyridin-2-amine

There total 8 articles about 5,6-Dibromopyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 5,6-dibromopyridin-2-ylamine (89284-11-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 1h; Cooling with ice;

Reference yield:

2,3,6-tribromopyridine (2402-92-8) → 5,6-dibromopyridin-2-ylamine (89284-11-7) + 3,6-dibromo-[2]pyridylamine (503425-86-3)

Guidance literature:

With ammonium hydroxide; at 150 - 160 ℃;

Reference yield:

2,4,6-tribromopyridine (2408-70-0) → 5,6-dibromopyridin-2-ylamine (89284-11-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NH₃ / 160 °C / Nebenprodukt Nr_. 2: 6-Brom-pyridin-2,4-diyldiamin

2: palladium/charcoal; methanol. NaOH / Hydrogenation

3: acetic acid; bromine

With ammonium hydroxide; sodium hydroxide; palladium on activated charcoal; bromine; acetic acid;

upstream raw materials:

2-Amino-6-bromopyridine

2,3,6-tribromopyridine

bromine

acetic acid

Downstream raw materials:

5,6-dibromo-N-nitropyridin-2-amine

2,3-dibromo-6-chloropyridine

5-bromo-6-(2-phenylethynyl)pyridin-2-amine