3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

Base Information

Chemical Name:3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid
CAS No.:1429474-18-9
Molecular Formula:C₁₈H₁₅Cl₂NO₂S
Molecular Weight:380.295
Hs Code.:

Synonyms:3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

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Chemical Property of 3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

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Technology Process of 3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

There total 3 articles about 3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1429474-17-8
3-(6-methyl-1H-indol-2-yl)propanoic acid

: 137897-99-5
1,2-bis(3,5-dichlorophenyl)disulfane

: 1429474-18-9
3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

Guidance literature:: 3-(6-methyl-1H-indol-2-yl)propanoic acid; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;

1,2-bis(3,5-dichlorophenyl)disulfane; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm301735k

Reference yield: 46.0%

: 1429474-18-9
3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;

In N,N-dimethyl-formamide; mineral oil; at 20 - 50 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1429474-16-7
methyl 3-(6-methyl-1H-indol-2-yl)propanoate

: 1429474-18-9
3-(3-((3,5-dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 16 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 24 h / 50 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm301735k