N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine
• CAS No.: 1395886-17-5
• Molecular Formula: C₁₉H₁₈ClN₅O₂
• Molecular Weight: 383.837
• Mol file: 1395886-17-5.mol

Synonyms:N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine

Chemical Property of N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine

There total 2 articles about N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(2-Hydroxyethyl)-4-aminobenzamide (54472-45-6) + N4-(2-chlorophenyl)-2-chloropyrimidine-4-amine (260046-05-7) → N4-(2-chlorophenyl)-N2-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine (1395886-17-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 140 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jm300334d

Reference yield:

o-chloroaniline (95-51-2) → N4-(2-chlorophenyl)-N2-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine (1395886-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 72 h / 20 °C

2: hydrogenchloride / water; ethanol / 0.5 h / 140 °C / Microwave irradiation

With hydrogenchloride; In ethanol; water;

DOI:10.1021/jm300334d

upstream raw materials:

N-(2-Hydroxyethyl)-4-aminobenzamide

N⁴-(2-chlorophenyl)-2-chloropyrimidine-4-amine

o-chloroaniline