4-Amino-N-(2-hydroxyethyl)benzamide

Base Information

• Chemical Name: 4-Amino-N-(2-hydroxyethyl)benzamide
• CAS No.: 54472-45-6
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2924299090
• Mol file: 54472-45-6.mol

Synonyms:4-Amino-N-(2-hydroxyethyl)benzamide;N1-(2-Hydroxyethyl)-p-aminobenzamide;Novasil;

Chemical Property of 4-Amino-N-(2-hydroxyethyl)benzamide

Chemical Property:

• Vapor Pressure: 4.94E-09mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 454 °C at 760 mmHg
• Flash Point: 228.4 °C
• PSA: 75.35000
• Density: 1.233 g/cm³
• LogP: 0.96300
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-N-(2-hydroxyethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43-36
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-N-(2-hydroxyethyl)benzamide is a useful synthesis intermediate.

Technology Process of 4-Amino-N-(2-hydroxyethyl)benzamide

There total 7 articles about 4-Amino-N-(2-hydroxyethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-hydroxyethyl)-4-nitrobenzamide (6640-65-9) → N-(2-Hydroxyethyl)-4-aminobenzamide (54472-45-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield: 77.0%

ethanolamine (141-43-5) + 4-methoxycarbonyl aniline (619-45-4) → N-(2-Hydroxyethyl)-4-aminobenzamide (54472-45-6)

Guidance literature:

With sodium methylate; In toluene; for 5h; Heating;

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → N-(2-Hydroxyethyl)-4-aminobenzamide (54472-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂ / 0.5 h / 0 °C

2: 7.3 g / H₂ / Pd/C / methanol

With TEA; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; 1: Acylation / 2: Hydrogenation;

DOI:10.1016/S0968-0896(99)00244-8

upstream raw materials:

N-(2-hydroxyethyl)-4-nitrobenzamide

ethanolamine

4-methoxycarbonyl aniline

4-nitrobenzoic acid methyl ester

Downstream raw materials:

4-(4,5-Dihydrooxazol-2-yl)aniline

4-(3-chloro-7-methoxyfuro[2,3-b]quinolin-4-ylamino)-N-(2-hydroxyethyl)benzamide

N₄-(2-chlorophenyl)-N₂-[4-N-(2-hydroxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine

4-hydroxy-4'-(N-hydroxyethyl)azobenzamide