{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Base Information

Chemical Name:{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid
CAS No.:72482-51-0
Molecular Formula:C₁₅H₈Cl₂FNO₄
Molecular Weight:356.137
Hs Code.:

Synonyms:{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

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Chemical Property of {[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

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Technology Process of {[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

There total 6 articles about {[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100814-78-6
n-butyryl hypobromite

: 628-13-7
pyridine hydrochloride

: 584-08-7
potassium carbonate

: 72482-50-9
7-chloro-3-(4-chloro-2-fluorophenyl)-6-methoxy-1,2-benzisoxazole

: 72482-51-0
{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

: [7-Chloro-3-(4-chloro-2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester

: 72482-51-0
{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Yield given;
DOI:10.1021/jm00343a008

Reference yield:

: 72482-48-5
2,3-dichloro-4-methoxy-4'-chloro-2'-fluorobenzophenone

: 72482-51-0
{[7-chloro-3-(4-chloro-2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride, pyridine / 24 h / Heating

2: sodium hydride / dimethylformamide / 1 h / Ambient temperature

3: BBr₃ / CH₂Cl₂ / Heating

4: sodium hydride / dimethylformamide / 0.5 h / 50 °C

5: aq. NaOH / dimethylformamide / 3 h / 90 °C

With pyridine; sodium hydroxide; hydroxylamine hydrochloride; boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008