(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Base Information

Chemical Name:(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide
CAS No.:866270-10-2
Molecular Formula:C₂₀H₂₆BrN₃O₄
Molecular Weight:452.348
Hs Code.:

Synonyms:(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

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Chemical Property of (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Chemical Property:

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Technology Process of (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

There total 9 articles about (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 866270-09-9
(S)-ethyl 5-(3-bromobenzyl)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]oxazole-4-carboxylate

: 866270-10-2
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Guidance literature:: With ammonia; In ethanol;
DOI:10.1021/jo0509760

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 866270-10-2
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / toluene / 1 h / Heating

2: 4.9 g / Et₃N / CH₂Cl₂ / 20 °C

3: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

4: 71 percent / SnCl₂ / CH₂Cl₂ / 4 h

5: 92 percent / 4-acetamidobenzenesulfonyl azide / acetonitrile / 16 h / 20 °C

6: 73 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

7: 65 percent / triphenylphosphine; iodine; Et₃N / CH₂Cl₂ / 16 h

8: 68 percent / NH₃ / ethanol

With lithium aluminium tetrahydride; thionyl chloride; rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; ammonia; iodine; triethylamine; triphenylphosphine; tin(ll) chloride; In diethyl ether; ethanol; dichloromethane; toluene; acetonitrile; 7: Robinson-Gabriel cyclodehydration reaction;
DOI:10.1021/jo0509760

Reference yield:

: 866270-03-3
2-(3-bromophenyl)-N-methoxy-N-methylacetamide

: 866270-10-2
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 71 percent / SnCl₂ / CH₂Cl₂ / 4 h

3: 92 percent / 4-acetamidobenzenesulfonyl azide / acetonitrile / 16 h / 20 °C

4: 73 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

5: 65 percent / triphenylphosphine; iodine; Et₃N / CH₂Cl₂ / 16 h

6: 68 percent / NH₃ / ethanol

With lithium aluminium tetrahydride; rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; ammonia; iodine; triethylamine; triphenylphosphine; tin(ll) chloride; In diethyl ether; ethanol; dichloromethane; acetonitrile; 5: Robinson-Gabriel cyclodehydration reaction;
DOI:10.1021/jo0509760