4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

Base Information

Chemical Name:4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide
CAS No.:1491141-82-2
Molecular Formula:C₃₀H₃₁ClFN₅O₄
Molecular Weight:580.059
Hs Code.:

Synonyms:4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

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Chemical Property of 4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

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Technology Process of 4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

There total 10 articles about 4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53750-66-6
4-chloro-pyridine-2-carbonyl chloride

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: 1491141-82-2
4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h; Cooling with ice;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1491141-82-2
4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

Guidance literature:: Multi-step reaction with 7 steps

1: dimethyl amine; toluene / 10 h / 110 °C

2: iron; acetic acid / 2.5 h / 20 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

6: iron; ammonium chloride / ethanol; water / 5 h / Reflux

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C / Cooling with ice

With iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; water; dimethyl amine; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 1449763-02-3
1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

: 1491141-82-2
4-chloro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)picolinamide

Guidance literature:: Multi-step reaction with 6 steps

1: iron; acetic acid / 2.5 h / 20 - 80 °C

2: acetonitrile / 10 h / 85 °C

3: trichlorophosphate / 6 h / 85 °C

4: chlorobenzene / 30 h / 140 °C

5: iron; ammonium chloride / ethanol; water / 5 h / Reflux

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C / Cooling with ice

With iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; acetonitrile;
DOI:10.1016/j.ejmech.2013.08.019