2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol

Base Information

• Chemical Name: 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol
• CAS No.: 341970-43-2
• Molecular Formula: C₃₆H₃₃NO₃
• Molecular Weight: 527.663

Synonyms:2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol

Chemical Property of 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol

Chemical Property:

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Technology Process of 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol

There total 3 articles about 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(4-tributylstanninobuta-1,3-diyn-1-yl)benzyl alcohol + (N-tert-butoxycarbonyl-N-diphenylmethyl)-2-iodobenzylamine (341970-36-3) → 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol (341970-43-2)

Guidance literature:

Pd₂(PPh₃)2Cl₂; In toluene; at 110 ℃; for 2h;

DOI:10.3987/com-00-s(i)88

Reference yield:

N-(tert-butoxycarbonyl)(diphenylmethyl)amine (21420-61-1) → 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol (341970-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide / 4 h / 0 - 20 °C

2: 79 percent / Pd₂Cl₂(PPh₃)2 / toluene / 2 h / 110 °C

With sodium hydride; Pd₂(PPh₃)2Cl₂; In N,N-dimethyl-formamide; toluene;

DOI:10.3987/com-00-s(i)88

Reference yield:

2-iodobenzyliodide (4622-38-2) → 2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzyl alcohol (341970-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide / 4 h / 0 - 20 °C

2: 79 percent / Pd₂Cl₂(PPh₃)2 / toluene / 2 h / 110 °C

With sodium hydride; Pd₂(PPh₃)2Cl₂; In N,N-dimethyl-formamide; toluene;

DOI:10.3987/com-00-s(i)88

upstream raw materials:

(N-tert-butoxycarbonyl-N-diphenylmethyl)-2-iodobenzylamine

N-(tert-butoxycarbonyl)(diphenylmethyl)amine

2-iodobenzyliodide

Downstream raw materials:

2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]benzaldehyde

1-[2-[4-(2-N-tert-butoxycarbonyl-N-diphenylmethylaminomethylphenyl)buta-1,3-diyn-1-yl]phenyl]-6,6-dimethyl-6-silahepta-2,4-diyn-1-ol

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