Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester
• CAS No.: 21420-61-1
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• DSSTox Substance ID: DTXSID40464506
• Nikkaji Number: J966.421A
• Wikidata: Q82289849
• Mol file: 21420-61-1.mol

Synonyms:21420-61-1;Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester;tert-butyl benzhydrylcarbamate;SCHEMBL14820895;DTXSID40464506;AKOS013099575

Chemical Property of Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 283.157228913
• Heavy Atom Count: 21
• Complexity: 305

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester

There total 21 articles about Carbamic acid, (diphenylmethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + Benzhydrylamine (91-00-9) → N-(tert-butoxycarbonyl)(diphenylmethyl)amine (21420-61-1)

Guidance literature:

aminosulfonic acid; at 25 - 28 ℃; for 0.05h;

DOI:10.1016/j.tetlet.2007.09.126

Reference yield: 91.0%

tert-butyl benzhydryl(3-methylpyridin-2-yl)carbamate (1370412-51-3) → N-(tert-butoxycarbonyl)(diphenylmethyl)amine (21420-61-1)

Guidance literature:

tert-butyl benzhydryl(3-methylpyridin-2-yl)carbamate; With methyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃;

With sodium hydroxide; In methanol; water; at 50 ℃; for 6h;

DOI:10.1021/ol300627p

Reference yield: 82.0%

tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate (155396-71-7) + phenylboronic acid (98-80-6) → N-(tert-butoxycarbonyl)(diphenylmethyl)amine (21420-61-1)

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; sodium dodecyl-sulfate; potassium carbonate; In water; toluene; at 150 ℃; for 0.166667h;

DOI:10.1016/j.ica.2010.09.056

upstream raw materials:

trimethyl(phenyl)stannane

benzaldehyde N-boc imine

Benzophenone oxime

di-tert-butyl dicarbonate

Downstream raw materials:

Benzhydrylamine

(E)-tert-butyl benzhydryl(buta-1,3-dien-1-yl)carbamate

t-butyl N-(diphenylmethyl)-N-[(2-bromophenyl)methyl]carbamate

6,7-dihydro-5-phenyl-5H-dibenz[c,e]azepine