2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1566583-81-0
Molecular Formula:C₂₂H₂₂F₃N₅O
Molecular Weight:429.445
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 11 articles about 2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1566584-43-7
tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

: 1566583-81-0
2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 4403-71-8
(4-aminomethyl)aniline

: 1566583-81-0
2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 18698-96-9
o-iodophenylacetic acid

: 1566583-81-0
2-(2-(2-(2-((4-(aminomethyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / water / 16 h / 80 °C / Inert atmosphere

2.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

4.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

4.2: 0.33 h / 120 °C / Microwave irradiation

5.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;