tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

Base Information

Chemical Name:tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate
CAS No.:1566584-43-7
Molecular Formula:C₂₇H₃₀F₃N₅O₃
Molecular Weight:529.562
Hs Code.:

Synonyms:tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

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Chemical Property of tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

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Technology Process of tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

There total 11 articles about tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1566584-42-6
2-(2-(2-(2-((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

: 1566584-43-7
tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 4403-71-8
(4-aminomethyl)aniline

: 1566584-43-7
tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1566584-43-7
tert-butyl 4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;